Based on the experimental data on heart rate variability (HRV) in rats in different conditions (anesthesia, immo-bilization stress, an experimental chronic heart failure) at short-term and long-term exposure to ?-adrenoblockers and short-term exposure to ?- adrenomimetics, an indicator of total degree of influence (ITDI) on the heart rate has been proposed. ITDI considerably facilitates data analysis and clearly demonstrates which of the test substances acting on HRV are stronger under given conditions. If ITDI is less than zero, the sympathetic and catecholaminergic system influences dominate in the heart rate activity. If ITDI is more than zero, the activity of the parasympathetic part of the autonomic nervous system prevails.
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