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Title of Article

EXPRESSION OF CANCER-TESTIS GENES IN PATIENTS WITH RENAL CARCINOMA


Issue
2
Date
2012

Section
PHYSICO-CHEMICAL BIOLOGY

Article type
scientific article
UDC
616-006.66
Pages
183-186
Keywords
 


Authors
Gurram Nazhat
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Novikov Dmitriy Viktorovich
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Alyasova Anna Valerevna
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Novikov Viktor Vladimirovich
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo


Abstract
In the current study, we have shown that in primary tumors and peripheral blood samples of renal cancer patients mRNAs of cancer-testis genes MAGE and GAGE/PAGE/XAGE are present. The genes express in different combinations and with different frequency. The spectra of gene expression differ, indicating the differences in transcriptome structure of malignantly transformed cells present in tumor sites and of metastatic cells circulating in the blood.

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