Вестник Нижегородского университета им. Н.И. Лобачевского. Серия: Социальные науки

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Title of Article

SOME FEATURES OF EXPRESSION OF DIFFERENTIATION-RELATED GENES IN CELL LINES DERIVED FROM PATIENTS WITH COLORECTAL CANCER

Issue	2
Date	2012

Article type	scientific article	UDC	616-006.66
Pages	241-245	Keywords

Authors

Shumilova Svetlana ViktorovnaNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Perenkov Aleksey DmitrievichNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Sakharnov Nikolay AleksandrovichNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Novikov Dmitriy ViktorovichNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Eksina Kseniya IgorevnaNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Filatova Elena NikolaevnaNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Baryshnikov Anatoliy YurevichRossiyskiy onkologicheskiy nauchnyy tsentr im. N.N. Blokhina RAMN, Moskva
Novikov Viktor VladimirovichNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Abstract

The expression profiles of genes encoding molecules CD25 (IL-2R?), CD38, CD95 (Fas), CD122 (IL-2R?) and CD132 (IL-2R?) were investigated in cell lines COLO 205, HCT116, HCT15, SW-620, T84, CaCo-2. The heterogeneity of CD38 and CD95 genes expression and the absence of CD25 mRNA were observed in cells. The study of CD25, CD38 and CD95 genes epigenetic regulation has shown that only in CD25 gene the methylation of regulatory elements is in strict conformity with the gene silence in tumor cells.

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