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Title of Article

Noninvasive monitoring of photosensitizer content in animal tissues by diffuse fluorescence tomography


Issue
3
Date
 2008

Article type
 scientific article
UDC
577.3
Pages
105-109
Keywords
 


Authors
Balalaeva I.V.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo, Institut prikladnoy fiziki RAN

Shirmanova M.V.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo, Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Zagaynova E.V.
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Orlova A.G.
Institut prikladnoy fiziki RAN

Karshieva S.Sh.
Rossiyskiy onkologicheskiy nauchnyy tsentr im. N.N. Blokhina RAMN, g. Moskva

Romanenko V.I.
Rossiyskiy onkologicheskiy nauchnyy tsentr im. N.N. Blokhina RAMN, g. Moskva


Abstract
The possibility of applying diffuse fluorescence tomography (DFT) for intravital whole-body monitoring of exogenous fluorophore distribution and excretion has been assessed. The study was conducted on mice, injected intravenously with photosensitizer Photosens. DFT images of animals at different time intervals after injection have been obtained and analyzed. The results of DFT-monitoring of photosensitizer content in animal tissues have been confirmed by fluorescence microscopy and spectroscopy data.

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