Two kidney one renal artery ligation resulted in an increased arterial pressure, raising the plasma concentration of creatinine in rats. Compensatory adaptive reversible changes of the ultrastructure predominated in the secretory cardiomyocytes of the right atrium whose granules contained atrial natriuretic peptide. An intensified secretion of atrial natriuretic peptide in blood has been observed, however, without any physiological effects. Probably, this was due to the reduced density of A type receptors for natriuretic peptides.
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