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Title of Article

ICAM-1 GENE EXPRESSION IN COLORECTAL CANCER CELLS


Issue
2
Date
 2010

Article type
 scientific article
UDC
571.2;616-006.6
Pages
528-531
Keywords
ICAM-1, colorectal cancer, cell adhesion, mRNA processing


Authors
Knyazev D.I.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Novikov D.V.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Sakharnova T.A.
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Presnyakova N.B.
Nizhegorodskiy NII epidemiologii i mikrobiologii im. I.N. Blokhinoy

Kuznetsova O.S.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Kazatskaya Zh.A.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Spiridonova N.A.
Nizhegorodskiy NII epidemiologii i mikrobiologii im. I.N. Blokhinoy

Alyasova A.V.
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Novikov V.V.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo, Nizhegorodskiy NII epidemiologii i mikrobiologii im. I.N. Blokhinoy


Abstract
It is shown that an increase in serum levels of soluble ICAM-1 in colorectal cancer patients is not associated with the presence of the alternative form of ICAM-1 mRNA in primary colorectal tumors. The alternative form is characterised by a deletion in the transmembrane region and encodes soluble ICAM-1. The presence of mRNA encoding soluble ICAM-1 in tumor cells, however, may be associated with a reduced risk of metastases.

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