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Title of Article

APITOXIN ADAPTOGENIC EFFECTS TO HYPOXIA AFTER PERORAL ADMINISTRATION


Issue
2
Date
2010

Article type
scientific article
UDC
599: 539.1.047
Pages
659-663
Keywords
bee venom, apitoxin, chitosan, nanoparticles, adaptogenic effects, hypoxia


Authors
Koryagin A.S.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Mochalova A.E.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Krylov V.N.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Smirnova L.A.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Salomatina E.V.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Nikolaeva A.A.
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo


Abstract
Adaptogenic effects of apitoxin in nanocomposite formulation after peroral administration have been studied on rats. The peroral administration of apitoxin in nanocomposites (gold nanoparticles-apitoxin-chitosan) to experimental animals in a dose of 0.5 mg/kg brings about the adaptation reaction of sustained activation and the reduction of free-radical oxidation processes under normal conditions, as well as an increased resistance to hypoxia in a week after the end of preparation administration that has been confirmed by the blood system indices.

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