THE EFFECT OF LYSOPHOSPHATIDYLCHOLINE AND EGG YOLK ON THE AMPLITUDE OF INDUCED CONTRACTIONS IN RAT MYOCARDIUM |
| 1 | |
| 2011 |
| scientific article | 612.173.3 + 612.123 + 612.392.83 | ||
| 110-116 | lysophosphatidylcholine, rat myocardium, contractility |
| Lysophosphatidylcholine (LPC) in concentrations 2 · 10-9 M - 2 · 10-4 M reliably and reversibly reduces the am-plitude of electrically stimulated contractions in myocardium of rat heart right ventricle and reduces the ability of cardiomyocytes to relaxation. These changes are explained by excessive accumulation of Са2 + ions inside cardio-myocytes that reduces the sarcomere length and thus reduces the force of heart contraction. |
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