Вестник Нижегородского университета им. Н.И. Лобачевского. Серия: Социальные науки

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Title of Article

SYNTHESIS OF LIPOPHILIC DERIVATIVES OF COLCHIFOLINE AND ALLOCOLCHIFOLINE

Issue	3
Date	2011

Article type	scientific article	UDC	543.645.3
Pages	120-125	Keywords	colchifoline, allocolchifoline, tubulin, antimitotic agent, liposome

Authors

Sitnikov Nikolay SergeevichNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Shavyrin Andrey SergeevichInstitut metalloorganicheskoy khimii im. G.A. Razuvaeva RAN
Fedorov Aleksey YurevichNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Malysheva Yuliya BorisovnaNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Abstract

Lipophilic derivatives of colchifoline and allocolchifoline have been synthesized starting from commercially available colchicine in 4 linear steps with overall yields of 35-52%. The obtained biodegradable compounds can be further incorporated into liposomal drug delivery systems. A plausible mechanism of a base-catalysed pericyclic rearrangement of colchicinoids into the corresponding allocolchicine derivatives has been proposed.

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