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Title of Article

INTERACTION OF CROSS-LINKED POLYACRYLIC ACID AND CARBOXYMETHYLCELLULOSE SODIUM SALT WITH XYMEDONE (1-(?-OXYETHYL)-4,6-DIMETHYL-1,2-DIHYDRO-2- OXOPYRIMIDINE) IN AN AQUEOUS MEDIUM


Issue
5
Date
2011

Section
CHEMISTRY

Article type
scientific article
UDC
541.64; 547.458.82
Pages
91-96
Keywords
xymedone, pyrimidine, gel, cross-linked polyacrylic acid, carboxymethylcellulose sodium salt, complex formation of xymedone with biopolymers


Authors
Melnikova Nina Borisovna
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Panteleev Dmitriy Aleksandrovich
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Zhiltsova Olga Evgenevna
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Volkov Aleksandr Aleksandrovich
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Gulenova Marina Valentinovna
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo

Salikova Tatyana Vladimirovna
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya


Abstract
An extreme dependence of pH, specific electrical conductivity, viscosity of carboxymethylcellulose sodium salt with xymedone (1-(?-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine) in an aqueous medium on xymedone concentration has been found. According to 13С NMR spectra, xymedone reacts in an aqueous medium with polyacrylic acid and binds the protons resulting from the dissociation of polyacrylic acid, which leads to an increase in pH and a decrease in specific conductivity. It is shown that the interaction of xymedone with polyacrylic acid is similar to the ligand absorption by biopolymers and may be described in the approximation of the Scatchard theory.

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