Вестник Нижегородского университета им. Н.И. Лобачевского. Серия: Социальные науки

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Title of Article

COMPARATIVE ANALYSIS OF CYTOTOXICITY AND THE EFFECT OF PLATINUM(IV) COMPLEXES WITH AMINONITROXYL RADICALS ON THE CELL CYCLE

Issue	2
Date	2011

Article type	scientific article	UDC	615.277.3
Pages	82-89	Keywords	platinum complexes, nitroxyl radicals, cytotoxicity, cell cycle

Authors

Komleva Natalya VladimirovnaInstitut problem khimicheskoy fiziki RAN, Chernogolovka
Kostyuk Galina VadimovnaInstitut problem khimicheskoy fiziki RAN, Chernogolovka
Parkhomenko Igor IvanovichInstitut problem khimicheskoy fiziki RAN, Chernogolovka
Balalaeva Irina VladimirovnaNizhegorodskiy gosuniversitet im. N.I. Lobachevskogo
Golubev Valeriy AleksandrovichInstitut problem khimicheskoy fiziki RAN, Chernogolovka
Sen Vasiliy DmitrievichInstitut problem khimicheskoy fiziki RAN, Chernogolovka
Terentev Aleksey AlekseevichInstitut problem khimicheskoy fiziki RAN, Chernogolovka

Abstract

Cytotoxicity and the effect of several platinum(IV) complexes with aminonitroxyl radicals on the cell cycle have been studied. Cytotoxic properties of the complexes increase with the lengthening of the alkyl chain of axial ligands. Platinum complexes kill HeLa cells, but they stop the cell cycle in H1299 cells. Cells of both types are most sensitive to the platinum complexes during S-phase of the cell cycle.

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