KINETIC PROPERTIES OF MITOCHONDRIAL ALCOHOL DEHYDROGENASE IN LIVER CELLS UNDER TOXIC HEPATITIS |
| 2 | |
| 2011 |
| scientific article | 577.151.4 | ||
| 222-224 | alcohol dehydrogenase, kinetics, mitochondria, toxic hepatitis, biotransformation |
| Kinetic properties of mitochondrial liver alcohol dehydrogenase under toxic hepatitis have been studied by a new kinetic method. It has been found that under toxic hepatitis there is a significant decrease in enzyme-reaction substrate affinity, mostly in the reverse enzymatic reaction, which leads to an increase in the proportion of highly toxic acetaldehyde in the liver cells. |
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