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Title of Article

INFLUENCE OF HEPARIN ON CARDIOTROPIC EFFECTS OF MELITTIN AND APITOXIN


Issue
2
Date
2011

Article type
scientific article
UDC
612.57
Pages
249-253
Keywords
apitoxin, melittin, heparin, isolated heart


Authors
Zvonkova Mariya Borisovna
Nizhegorodskiy gosudarstvennyy pedagogicheskiy universitet

Pursanov Kuzma Anastasovich
Nizhegorodskaya gosudarstvennaya meditsinskaya akademiya

Khomutov Aleksandr Evgenevich
Nizhegorodskiy gosuniversitet im. N.I. Lobachevskogo


Abstract
In the experiments on sexually mature male rats, the influence of heparin on cardiotropic effects of apitoxin and melittin has been studied on the isolated rat heart. Apitoxin and melittin have been shown to decrease the heart rate, the maximum pressure in the left ventricle, the speed of contraction and relaxation. Heparin injected in the mixture with apitoxin and melittin blocks their cardiotropic effects.

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