A new method of spheres is presented to study the morphology of biological objects. The method calculates the surface-to-volume ratio (SVR) in the neighborhood of an arbitrary point on the object’s polygonal mesh surface in order to estimate its local metabolic conversion efficiency. To prove the method validity we have studied quantitative local morphology estimates of some artificial morphologically complex objects and brain cells. A computationally efficient algorithm for the local SVR calculation is described. A relation between the SVR, calculated by the method of spheres, and the mean surface curvature has been studied by the typical examples of morphologically complex objects..
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