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Title of Article

M-CHOLINOBLOCKER ACTIVITY OF HUMAN BLOOD SERUM IN THE EXPERIMENTS WITH PORCINE CORONARY ARTERY RING SEGMENTS


Issue
2
Date
2014

Article type
scientific article
UDC
612.73+612.118.2+612.172.1+612.181.5
Pages
133-139
Keywords
coronary artery, blood serum, acetylcholine, cholinoreceptors, coronary heart disease


Authors
Chulkina E.A.
Vyatskiy gosudarstvennyy gumanitarnyy universitet, Kirov; Kirovskaya gosudarstvennaya meditsinskaya akademiya

Gulyaeva S.F.
Kirovskaya gosudarstvennaya meditsinskaya akademiya

Tsirkin V.I.
Kazanskiy gosudarstvennyy meditsinskiy universitet

Kostyaev A.A.
Kirovskiy NII gematologii i perelivaniya krovi


Abstract
10-, 50-, 100-, 500-, and 1000-fold dilutions of venous serum of healthy women, healthy men and men with coronary heart disease were studied in the experiments with 195 ring segments of the porcine right coronary artery. Human serum provides M-cholineblocking activity that can be explained by the presence of an endogenous non-selective M-cholinoreceptor blocker whose content depends on the gender and the presence of coronary heart disease.

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