OXIDATIVE MODIFICATION OF HUMAN SERUM ALBUMIN IN INFLAMMATORY SKIN DISEASES |
| 3 | |
| 2014 |
| scientific article | 616-07:061.62:616.5 | ||
| 65-69 | acne, oxidative modification of albumin, albumin, systemic retinoids |
| 32 patients with inflammatory skin diseases have been examined to study the degree of oxidative modification of serum albumin. The quantitative content of modified and effective serum albumin and its carbonyl derivatives were evaluated. We have found out a statistically significant decrease in the effective albumin concentration and an increase in the level of ketone carbonyl groups (370 nm) during spontaneous and induced oxidative modifications of protein in patients with inflammatory skin processes relative to the control group. It has been revealed that by the end of treatment with systemic retinoids the level of spontaneous oxidative modification of albumin decreases and the content of effective albumin increases. |
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